Formulating Poorly Water Soluble Drugs

Contents

1. Route-Specific Challenges in the Delivery of Poorly Water-Soluble Drugs .................... Zachary Warnken, Hugh D.C. Smyth, and Robert O. Williams III

2. Optimizing the Formulation of Poorly Water-Soluble Drugs................................ Xiangyu Ma, Daniel Ellenberger, Kevin P. O'Donnell, and Robert O. Williams III

3. Solid-State Techniques for Improving Solubility ............................................... Miguel O. Jara, Justin R. Hughey, Siyuan Huang, and Robert O. Williams III

4. Mechanical Particle-Size Reduction Techniques................................................ Javier O. Morales, Alan B. Watts, and Jason T. McConville

5. Co-solvent and Complexation Systems ....................................................... Junhuang Jiang and Robert O. Williams III

6. Injectable Formulations of Poorly Water-Soluble Drugs ..................................... Hannah L. O'Mary and Zhengrong Cui,

7. Lipid-Based Formulations............................................................................ Daniel A. Davis Jr., Han-Hsuan Peng, and Robert O. Williams III

8. Structured Development Approach for Amorphous Systems ............................... Susanne Page, Reto Maurer, Nicole Wyttenbach, and Felix Ditzinger

9. Melt Extrusion.................................................................................. Stephen A. Thompson, Daniel A. Davis Jr., James C. DiNunzio, Charlie Martin,
Robert O. Williams III, and Feng Zhang

10. Spray-Drying Technology............................................................................ Dave A. Miller, Daniel Ellenberger, Tiago Porfirio, and Marco Gil

11. Pharmaceutical Cryogenic Technologies .................................................... Sawittree Sahakijpijarn, Chaeho Moon, and Robert O. Williams III

12. Precipitation Technologies for Nanoparticle Production .................................. Tuangrat Praphawatvet and Robert O. Williams III

13. Emerging Technologies to Increase the Bioavailability of Poorly Water-Soluble Drugs ...
Daniel A. Davis Jr., Rishi Thakkar, Mohammed Maniruzzaman, Dave A. Miller, Robert O. Williams III

14. Scientific and Regulatory Considerations for Development and Commercialization of Poorly Water-Soluble Drugs............................................................................ .Zedong Dong and Hasmukh Patel