Natural Products from Actinomycetes: Diversity, Ecology and Drug Discovery

Section 1: Diversity, Chemical biology and Ecology of Actinomycetes; and the Discovery of Natural Products

Chapter 1: An overview on Natural products from Actinomycetes: their discovery and biosynthesis.

Chapter 2: Isolation, identification (cultural and molecular techniques), and systematics of Actinomycetes from various sources (marine, soil, extremophilic environment).

Chapter 3: Studies on diversity of nonribosomal peptide synthetase and polyketide synthase gene clusters among taxonomically close Actinomycetes strains.

Chapter 4: Chemical elicitors and signaling molecules and their role in elicitation of secondary metabolism in Actinomycetes.

Chapter 5: Regulation of antibiotic biosynthesis genes in Actinomycetes at molecular level.

Chapter 6: Screening strategies for inhibitors against cancer cells from natural Products repository of Actinomycetes.

Chapter 7: Rare and endophytic Actinomycetes in the biosynthesis of bioactive metabolites.

Chapter 8: Advances in bioactivity guided isolation of natural products from Actinomycetes.

Chapter 9: Natural product discovery from non-Streptomyces Actinomycetes.

Chapter 10: Use of high-efficiency CRISPR/Cas9-mediated genome editing to study biology of Actinomycetes.

Section 2: Genomic approaches and synthetic biology tools in Actinomycetes drug discovery and industrial compounds

Chapter 11: An overview of biomedical, biotechnological and industrial applications of Actinomycetes

Chapter 12: Genomics and proteomics approach in natural product discovery in Actinomycetes.

Chapter 13: Structural dereplication and strain dereplication strategies and metabolomics in natural product research.

Chapter 14: Genome mining of rare Actinomycetes and cryptic pathways for secondary metabolites.

Chapter 15: Glycosylated bioactive compound discovery by from Actinomycetes by combination of genome mining, gene inactivation and activation of silent biosynthetic clusters.

Chapter 16: Genetic engineering for overproducing bioactive secondary metabolites in Actinomycetes

Chapter 17: Transcriptional gene cluster refactoring for increased secondary metabolites production

Chapter 18: Synthetic biology in Actinomycetes for natural product discovery

Chapter 19: Metabolic engineering of antibiotic factories: new tools for antibiotic production in Actinomycetes

Chapter 20: Bioinformatic tools for use in pks and nrps discovery in Actinomycetes.