New Strategies Targeting Cancer Metabolism: Anticancer Drugs, Synthetic Analogues and Antitumor Agents

New Strategies Targeting Cancer Metabolism: Anticancer Drugs, Synthetic Analogues and Antitumor Agents presents up-to-date synthetic strategies for three categories of antimetabolites: antifolates, purines and pyrimidines, the main classes of antimetabolites which are integrated into various pharmaceutical agents. Many of these antimetabolites are considered potent chemotherapeutic agents which have great impact potential on the current medicinal research. These main classes of antimetabolites are used in the treatment of critical diseases including cancer, malignancies, chronic inflammatory diseases, malaria, psoriasis, gastrointestinal diseases, microbial, Alzheimer's disease, influenza virus, hepatitis C (HCV), HIV, rheumatoid arthritis and other autoimmune diseases.

In this book, insights into a broad array of novel compounds are reviewed, well-recognized synthetic approaches are emphasized for further drug development and discovery, and the biological evaluation of novel synthesized compounds are included. This comprehensive reference is a valuable resource for medicinal chemists working in drug discovery and development, as well as pharmacologists and biochemists working in related fields.