Pharmacological Advances in Central Nervous System Stimulants: Volume 99

Stimulants are a class of drugs that have important therapeutic applications but are also subject to abuse. In the midst of the intense focus on opioids abuse, stimulant abuse is rising around the world. This volume, Mechanism, therapeutic uses and abuse of stimulants, showcases recent pharmacological progress investigating both therapeutic (ADHD, binge-eating and narcolepsy) and abuse aspects of a number of stimulants, some of which are long-standing (amphetamines, cocaine and nicotine) while others are emerging (cathinones). The reviews presented in this volume discuss the effects of stimulants on molecular processes, such as epigenetic changes, as well as behaviors in humans and laboratory animals. Dissimilarities in actions and effects of the stimulants in males and females are described. Part of the volume is devoted to factors that influence the interaction of amphetamines, cathinones and cocaine at their main sites of action, the monoamine transporters.